[ effect Allium ampeloprasum feeding on serum level of glucose, triglyceride, and total cholesterol of diabetic rats]

ABSTRACT

Use of medicinal plants for attenuation of hyperglycemia and restoration of lipids to normal level is clinically important. Since garlic and leek are similar regarding some effective substances as well as the antidiabetic effect of garlic, this study was performed to evaluate the effect of chronic oral administration of leek [Allium ampeloprasum] on serum level of glucose, triglyceride, and total cholesterol of diabetic rats. In the current study, 36 male Wistar rats were randomly divided into 4 groups, i.e. control, AA-treated control, diabetic, and AA-treated diabetic group. The treatment groups received oral administration of plant-mixed pelleted food [6.25%] for 4 weeks. Serum glucose, triglyceride, and total cholesterol levels were measured in all animals prior to the treatmen as well as two and four weeks after the treatment. Serum glucose levels were increased 4 weeks after the treatment in diabetic group compared to those levels was observed one week before the treatment [P<0.0001] and also AA treatment of diabetic rats did exert a significant hypoglycemic effect as compared to untreated diabetics [p<0.05]. In addition, triglyceride levels were increased 4 weeks after the treatment in the diabetic group in comparison with related levels observed one week prior to the treatment [P<0.05] and there was a significant lower level of triglyceride in AA-treated diabetic rats [p<0.05]. Furthermore, a similar significant reduction was obtained for treated-diabetic group as compared to diabetic group regarding serum cholesterol level [p<0.01]. Oral chronic administration of AA could reduce serum glucose, triglyceride, and cholesterol levels of STZ-diabetic rats