Decreasing efficacy of repeated intravitreal triamcinolone injection in diabetic macular oedema

ABSTRACT

To assess the efficacy of 4mg of repeated intravitreal injection of triamcinolone for the treatment of diabetic macular oedema. This is a case series of twenty eyes of twenty patients who received repeated injections of 4 mg of intravitreal triamcinolone at least 24 weeks after the first injection The best corrected visual acuity was compared after the first and repeated injection of intravitreal triamcinolone and at 2, 4, 8 and 12 weeks after the first and repeated injection of intravitreal triamcinolone using the paired t test. Side effects were also monitored. The best corrected visual acuity was significantly less in the repeated intravitreal injection at all follow ups [p <0.05] as compared to the initial injection of triamcinolone .The rise in the intraocular pressure and the cataract score were not significantly different in the initial and repeated injections of intravitreal triamcinolone. The repeated injection of 4 mg of intravitreal triamcinolone is not as effective as the initial injection of the same dose