[Association of major dietary Patterns with markers of systemic inflammation among women]

ABSTRACT

Few studies have examined the implication of major dietary patterns on plasma level of markers of inflammation. This study was conducted to evaluate the association of major dietary patterns with markers of systemic inflammation among Iranian women. In this cross-sectional study on 486 healthy women aged between 40 and 60, we assessed usual dietary intakes by means of a food-frequency questionnaire. Dietary patterns were identified by factor analysis. Anthropometric measurements were performed and fasting blood samples were taken for measuring inflammatory markers. The healthy pattern [high in fruits, vegetables, tomato and etc.] was inversely related to plasma concentrations of C-reactive protein [CRP] [beta=-0.09, P<0.001], E-selectin [beta=-0.07, P<0.05] and soluble vascular cell adhesion molecule-1 [sVCAM-1] [beta=-0.08, P<0.001]. After controlling the potential confounders [further adjustment for BMI and waist circumference], the associations still remained significant for CRP [beta=-0.05, P<0.05] and sVCAM-1 [beta=-0.04, P<0.05]. In contrast, the western pattern [high in refined-grains, red meat, butter and etc] was positively related to CRP [beta=0.08, P<0.001], serum amyloid A [SAA] [beta=0.11, P<0.05], IL-6 [beta=0.09, P<0.001], soluble intercellular adhesion molecule-1 [sICAM-1] [beta=0.05, P<0.05] and sVCAM-1 levels [beta=0.07, P<0.05]. however, after additional control for BMI and waist circumference, the associations remained significant just for SAA [beta=0.06, P<0.05] and interleukin-6 [IL-6] [beta=0.07, P<0.001]. The traditional dietary pattern [high in refined grains, potato, tea, whole-grains and so on] was positively associated with plasma levels of IL-6 [beta=0.04, P<0.05] when we controlled for confounders including BMI and waist circumference. Our findings suggest an independent association between major dietary patterns and plasma concentrations of markers of inflammation. Indeed, this issue provides further support of the concept that effects of nutritional pattern on chronic diseases are being exerted via the inflammatory biomarkers