Effect of toxic drug on liver function

ABSTRACT

The objective of this study was to evaluate the effect of Ivermectin on liver function of rats [Ivermectin is used as antiparasitic drug in agricultural and domestic animals.] In this study sixty adult male albino rats [150 +/- 10g] raised in a farm of General Organization of Serum and Vaccine [Helwan farm] were used. They were classified into 3 groups Control [group I], Subacute Oral toxicity [Group H], and Subchronic Oral Toxicity [Group III]. Blood samples and Tissue samples of liver were collected. Serum aspartate amino transferase [AST] alanine amino transferase [ALT], gamma_glutamyl transferase [GGT] and alkaline phosphatase were determined. Hepatic malondiadehyde [MDA], glutathione [GSH], glutathione -5-transferease [GST] and uridine diphosphate glutamyl transferase [UDPGT] were determined. The following results were recorded Serum AST, ALT, ALP and GGT activities were found to be significantly increased in group II and III compared with control and Alkaline phosphatase increase in group II compared to control. There was significant increase of MDA and decrease of GSH in group II and III compared with control group. Also, Ivermectin induced a significant inhibition of GST in group II and III compared with control group. However, Ivermectin caused a significant increase of UDPGT activity only in group II compared with control group. In addition, a non significant change between group II and III as observed with respect to UDPGT activity. In conclusion the present study reported that Ivermectin pesticide may have a harmful effects on liver. Further research will be done in future to investigate this hypothesis: