Influence of chelation therapy on acute cooper intoxication in the Egyptian toad Bufo regularis

ABSTRACT

1. Copper accumulation [in liver, kidney, blood and muscles] and nine non cellular blood components [alkaline phosphatase, glutamic pyruvic transaminase, total lipids, triglycerides, cholesterol, lipoproteins, glucose, total proteins and protein fractions] were measured in copper poisoned toad Bufo regularis before and after treatment with some chelating agents [disodium ethylenediaminetetraacetate [EDTA], trisodium citrate and sodium salicylate]. 2. Results indicated that EDTA was superior to both citrate and salicylate regarding treatment schedules of most of the parameters studied. 3. The agents citrate and salicylate should not be considered for use as they did not show marked protection against effects of copper