aspirin alter the pharmacokinetic of metformin?

ABSTRACT

The main goal to study the pharmacokinetics of Metformin is to help physicans to determine the accurate dose of Metformin that enable them to have good glycemic control in patient with type II diabetes mellitus. Many medicines alter the pharmacokinetics of Metformin and that make modifying of the dose necessary. To study the interaction between Metformin and another medicines which are commonly used together. We choose to study the interaction between the Aspirin and Metformin, in patients with type II diabetes mellitus. Fifteen male volunteers [25-40 years] received oral Metformin [500 mg] every 12 hours for 4 days, Aspirin [325 mg] every 12 hours in combination of oral Metformin [500 mg] every 12 hours for 4 days. Plasma samples were collected on day 4 of each regimen. The result showed that coadministration of Metformin and Aspirin had no significant effects on the steady state pharmacokinetics [AUC 0-12 h, C[max], T[max] or T[1/2]] of Metformin in patient with type II diabetes mellitus