Effect of cherries, cinnamon, coffee and parsley on hyperuricemia in rats fed high fructose diet

ABSTRACT

Hyperuricemia can be caused by overproduction of uric acid, as by feeding high fructose diets, or by inefficient excretion by the kidneys, and has long been associated with cardiovascular disease, and in people with hypertension, metabolic syndrome as gout or kidney disease. The study was carried out to investigate the effect of cherries [5%], cinnamon [5%], coffee [5%] and parsley [5%] on hyperuricemia in rats fed high fructose diet [60%] for four weeks. The results indicated that, all supplemented groups [with coffee, cherry, cinnamon or parsley] showed significant decrease [P < 0.05] in serum uric acid, creatinine, and urea nitrogen as compared to positive control group [+ve]. Also, feeding rats with coffee, cinnamon or parsley caused significant decrease [P < 0.05] in serum glucose, total cholesterol, triglycerides, VLDL-C, LDL-C as compared to both -ve and +ve controls. Feeding Cherry caused significant improvement in lipid profile, and did not affect significantly serum glucose and LDL-C. It could be concluded that, cherries, cinnamon, coffee and parsley reduce serum uric acid, urea and creatinine levels and improve kidney and liver functions. The study recommends a possible dietary supplementation with cherries, cinnamon, coffee and parsley for patients suffering from hyperuricemia, hypercholesterolemia and hyperglycemia