Antioxidant activity of a standardized sample of the Unani drug, Abresham [Bombyx mori Cocoon] with Vit. E as standard
Hamdard Medicus. 2008; 51 (1): 44-51
en Inglés
| IMEMR
| ID: emr-86515
ABSTRACT
Many natural drugs of Traditional Medicine have been shown to possess anti-oxidant activity. Unani Medicine, practised from Morocco to India, is likely to possess outstanding antioxidants. So, the Unani drug, Abresham [Silk Bombyx mori] Cocoon]. was studied for its effect on lipid Peroxidatior, [TBARS], SOD [Superoxide dismutase] and Catalase, The drug was also subjected to amino acid analysis, successive extraction etc. for physico-chemical characterization. After 7-day oral treatment with 175 mg/kg of 50% ethanolic extract of Abresham [Silk Cocoon] and Vit.E as the standard antioxidant for comparison, the rats were subjected to immobilization stress and the post-mitochondrial supernatant of Iiver was used for estimating the team parameters. The MDA concentration was decreased and SOD and Catalase activity were increased not only vis a vis the untreutcd and Vit.E - treated stressed animals but even the unstressed animals [P<0.001]. So, the Unani drug Abresham [Silk Cocoon is shown to possess a striking antioxidant effect. The remarkable increase in both SOD and Catalase, that effectively block the generation of Reactive Oxygen Species [ROS] in two successive steps, indicates that the test drug's antioxidant effect is exerted mainly by ROS generation blockade
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Bombyx
/
Superóxido Dismutasa
/
Vitamina E
/
Peroxidación de Lípido
/
Catalasa
/
Ratas Wistar
/
Medicina Unani
/
Tocoferoles
/
Medicina Tradicional
Límite:
Animales
Idioma:
Inglés
Revista:
Hamdard Med.
Año:
2008
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