influence of some dopamigergic agents on serum prolactin concentrations in male rats

ABSTRACT

The effects of several dopaminergic agents on prolactin [PRL] release were determined in male rats. The central nervous system stimulant, 4 aminopyridine, which affect turnover of monoamines [2.6 mg/kg] induced a non significant decrease in serum PRL level, while dopamine precursor L-dopa [100 mg/kg] resulted in a significant inhibition on PRL levels. Pencillamine and discultiram, a dopamine beta-hydroxylase inhibitors at a dose of 300 and 480 mg/kg respectively, had no effect on serum PRL level. It is concluded that neurotransmitter dopamine is responsible for inhibition of PRL release, since the dopamine precursor L-dopa inhibits PRL and the dopamine receptor blocker haloperidol [HAL] increases its release