Evaluation of some drug solvents for teratological investigation in rats

Female rats were treated by oral administration of 0.2 ml. of 10% solution of propylene glycol in distilled water or by 0.2 ml. olive oil. These doses were found to have no toxic effects on rats [El-Shabrawy, 1980]. Treatments were put to fulfill pre-mating and/ or during pregnancy exposure of animals to propylene glycol or olive oil. Significancy reduction in postnatal body weights was found in offspring from females treated with olive oil before mating and continued during the 1[st] 10 days of pregnancy. Non-significant results indicative of maternal toxicity, embryotoxicity or teratogenicity were obtained in any of the treated groups