Mycophenolate mofetil in the treatment of systemic discoid lupus erythematosus

ABSTRACT

The mycophenolate mofetile has been succesfully used for the treatement of several autoimmune skin diseases in a case of a 27 year old fenale patient, who was diagnosed as acute disseminater SLE in may 2002, according to the ARA document revised in 1987. Two years later, she had an intrauterine fetal death of 32 weeks, causing a severe, psychological impact. She complained of a generalised discoid lupus C face, thorax and both upper and lower limbs]. Due to the resistant oral and local hydroxychloroquine and local dapsone treatment, she had cortisonic diabetes, aseptic necrosis of the head of the femur, and macular toxicity caused by antimalarial therapy. The skin lesions was associated with proliferative segmental and focal lupus nephritis. Induction treatment with 29 per day of mycophenolate mofetil associated with corticaltherapy by prenidsone 1 mg/ kg/ id lead to the dissaperance of the skin lessions and porteinurea