Iron status and hemoglobin level on chronic renal insufficiency

To correlate the iron status and hemoglobin levels in pre End Stage Renal Disease [ESRE] patients with various degrees of chronic renal insufficiency. A cross sectional analytical study. Department of Physiology, BMSI, JPMC, Karachi, in collaboration with Department of Nephrology, JPMC, Karachi and the above mentioned departments. The study included 120 subjects, distributed into four groups with 30 subjects in each group. There were 15 male and 15 female subjects in each group. First group [control] comprising of normal subjects with Creatinine Clearance above 90 milliliters per minute [Cr. Cl > 90 mI/mm] and remaining three groups i.e., group 11 [Cr. Cl 60-90 mI/mm], group Ill [Cr. Cl 30-59 mI/mm], and group IV [Cr.Cl 15-29 mI/mm] comprising of patients with increasing severity of the renal insufficiency. Their hemoglobin, serum ferritin, serum iron and Total Iron Binding Capacity [TIBC] were analyzed and statistically compaied. As compared to control group. there was a 6.85%, 11.46%, 29.09% decrease in hemoglobin levels in males while 5. 13%, 9.24% and 24.24% decrease in females, when subjects of group II, III, and IV were taken into consideration. Similarly there was 2.82%, 783%, and 12.37% decrease in serum iron, 1.31%, 1.79% and 2.24% rise in Total Iron Binding Capacity [TIBC] and 1.78%, 11.79% and 29.47% decrease in serum ferritin levels in corresponding groups in the same order. The rate of decrease in hemoglobin level corresponds with the rate of deterioration in renal function; however the rate of change in iron profile is by and large within normal limits and hence is not very significant