Your browser doesn't support javascript.
loading
role of CYP2C9 gene polymorphisms on anticoagulant therapy after heart valve replacement
Medical Principles and Practice. 2008; 17 (6): 464-467
en Inglés | IMEMR | ID: emr-89023
ABSTRACT
The aim of the present study was to investigate the role of CYP2C9 gene polymorphisms after heart valve replacement in a group of patients on warfarin therapy. The study population consisted of 74 patients with heart valve replacement. Peripheral blood was collected into evacuated tubes containing EDTA, and DNA was extracted from circulating leukocytes by using a high pure PCR template preparation kit. CYP2C9*2, CYP2C9*3 alleles were detected by using real-time PCR. The patients with CYP2C9*1/*3 and CYP2C9*2/*3 genotypes were taking 28.21 and 24.47 mg, respectively, as mean weekly warfarin dose, whereas patients with CYP2C9*1/*1 genotype were taking 33.90 mg. The data show that patients with CYP2C9*1/*3 and CYP2C9*2/*3 genotypes needed a lower maintenance dose of warfarin than patients with CYP2C9*1/*1 wild-type genotype
Asunto(s)
Buscar en Google
Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Warfarina / ADN / Prótesis Valvulares Cardíacas / Hidrocarburo de Aril Hidroxilasas / Reacción en Cadena de la Polimerasa / Relación Normalizada Internacional / Anticoagulantes Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Med. Princ. Pract. Año: 2008

Similares

MEDLINE

...
LILACS

LIS

Buscar en Google
Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Warfarina / ADN / Prótesis Valvulares Cardíacas / Hidrocarburo de Aril Hidroxilasas / Reacción en Cadena de la Polimerasa / Relación Normalizada Internacional / Anticoagulantes Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Med. Princ. Pract. Año: 2008