[Effects of leukocyte-depletion filters on alluimunization derived reactions of platelet transfusion in acute leukemic patients]

ABSTRACT

Leukemia is the most common malignancy among adults and children which may develop several side affects such as anemia, infection and thrombocytopenia-related hemorrage. Many modalities have been suggested for prevention of Alluimunization and one of them is using of leukocytes free products. In fact, platelets could not solely stimulate immune reaction. This study is conducted at two hospials of "Shohada" and " Taleghani" to demonstrate the usefulness of such products. This research is a single- blinded clinical trial. All the patients had acute leukemia. In control group [24 subjects] we used a routin infusion set for transfusion and in experimental group [20 subjects] a biofilter was applied during the transfusion, platelet were counted one hour and 24 hr after transfusion. CCI formulate was used to represent a signs for Alluimunization. If CCI was less than 10x10 L/M[2] after transfusion or it became below 5-7x10 L/M[2] after 18-24 hr, the subject was considered alluimmune. After one hour, 21 cases out of 24 were alluimmuned in control group whereas in experimental group 13 cases from 20 patients became alluimmune. After 24 hours, 5 cases in control group and 5 ones in experiments were found to be Alluimmune. We did not prove any preventive properties from leukocyte-depletion filters in reducing the risk factors of Alluimunization amongs patients with acute leukemia