Effect of heat on the pattern of distribution of immunoglobulins

ABSTRACT

Eighteen male healthy volunteers were exposed to 40 degree C and 40 percent Relative Humidity [R.H.] for 80 minutes [test time] in an acclimatization chamber, this was proceeded by a period of 60 minutes at 25 degree C [control time] and 40 percent R.H. in the same chamber. The three major immunoglobulins, IgG, IgA and IgM, were estimated by the immuno diffusion plates, total protein. Albumin and Hb were also estimated at control and test time. No relation was shown between rise of body temperature and IgM or IgA contrary to IgG. The relation between body temperature and IgG was evident irrespective to total globulins and blood volume calculated from haemoglobin. Rise of body temperature above 0.5 degree C showed major changes in IgG level