Vitamin E derivative alpha-tocotrienol failed to show neuroprotective effects after embolic stroke in rats
Iranian Journal of Basic Medical Sciences. 2009; 12 (1): 9-17
en Inglés
| IMEMR
| ID: emr-91404
ABSTRACT
Previous studies have demonstrated that pretreatment with alpha-tocotrienol [a-TCT] can reduce ischemic damage in mice following middle cerebral artery [MCA] occlusion. It is also reported to decrease stroke dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present study, the neuroprotective effects of a-TCT and rosiglitazone [RGZ] at 3 hr after cerebral ischemia were investigated. Stroke was induced by embolizing a preformed clot into the MCA. Rats were assigned to vehicle, a-TCT [1 or 10 mg/kg], RGZ and sham-operation. Compared to the control group, only RGZ decreased infarct volume [P<0.05], neurological deficits [P<0.05] and sensory impairments [P<0.01] but low and high doses of a-TCT did not show any significant neuroprotective effect. Our data showed that a-TCT was not neuroprotective at 3 hr after the embolic model of stroke. Further studies should be undertaken to clarify the neuroprotective effects of a-TCT after stroke
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Daño Encefálico Crónico
/
Ratas Wistar
/
Fármacos Neuroprotectores
/
Accidente Cerebrovascular
/
Infarto de la Arteria Cerebral Media
/
Tocotrienoles
Límite:
Animales
Idioma:
Inglés
Revista:
Iran. J. Basic Med. Sci.
Año:
2009
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