Serum arylesterase activity is negatively correlated with inflammatory markers in patients with acute coronary syndromes

ABSTRACT

To examined whether serum paraoxonase [PON1] and arylesterase [ARE] activities are correlated with inflammatory biomarkers [procalcitonin and high sensitivity C-reactive protein [hs-CRP] in patients with acute coronary syndrome [ACS]. This cross-sectional study was conducted at the Departments of Cardiology and Biochemistry, Uludag University School of Medicine, Bursa, Turkey, from April 2007 to December 2007. Seventy-eight consecutive patients with ACS and 39 healthy controls were investigated. Acute coronary syndrome patients were divided into 3 groups according to their clinical presentation unstable angina pectoris [UAP] [Braunwald III-B, n=25], non-ST elevation myocardial infarction [NSTEMI] [n=18], and ST-elevation myocardial infarction [STEMI] [n=35]. Serum PON1/ARE activities were measured spectrophotometrically. Levels of procalcitonin and hs-CRP were measured by immunoassay. Paraoxonase/ARE activities were significantly lower in all patient groups compared to controls. No correlation between PON1/ARE activities and high-density-cholesterol levels was seen. Among ACS patients, serum ARE activity correlated inversely with baseline and 48-hour procalcitonin [r=-0.577, p=0.009, and r=-0.642, p=0.019] and hs-CRP levels [r=-0.614, p=0.03, and r=-0.719, p=0.044]. Serum ARE activity is reduced in ACS patients and inversely correlated with inflammatory markers