Synthesis and antitumor activity of some 5H-pyrrolizine, pyrimido [5, 4-a] pyrrolizine pyrimido [4, 5-b] pyrrolizine derivatives
SPJ-Saudi Pharmaceutical Journal. 2009; 17 (1): 3-18
en Inglés
| IMEMR
| ID: emr-92827
ABSTRACT
Seven new series of condensed pyrrolizine derivatives of anticipated antitumor activity have been synthesized. Comprises ethyl-1-cyano-3-phenylcarbamoyl-6, 7-dihydro-5H- pyrrolizin-2-yl-carbamate, 2, 4-dioxo-1H-pyrimido [4, 5-b] pyrrolizine-9carbonitrile, 1-cyano-2 [3-substituted ureido]-3N-phenyl-6, 7-dihydro-pyrrolizine-3-carboxamide, 3- [alkyl / phenyl]-4-imino-2-oxo-9N-phenyl-2, 3, 4, 5, 6, 7-hexahydro-1H-pyrimido [5, 4-a] pyrrolizine-9-carboxamide, 4-arnino-3-[alkyl / phenyl]-2-oxo-2, 3, 4, 5, 6, 7-hexahydro-1H-pyrimido [5, 4-a] pyrrolizine-9-carboxamide, of 2-amino-3N-phenyl-6, 7-dihydro-5H-pyrrolizine-1, 3-dicarboxamide and 4-oxo-9N-phenyl-4. 5, 6, 7-tetrahydro-3H-pyrimido [5, 4-a] pyrrolizin-9-carboxamide derivatives. Eleven were screened for their in vitro antitumor activity and ten compounds proved to possess moderate to weak activities
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Pirimidinonas
/
Alcaloides de Pirrolicidina
/
Antineoplásicos
Idioma:
Inglés
Revista:
Saudi Pharm. J.
Año:
2009
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