Effects of relaxation and citalopram on severity and frequency of the symptoms of irritable bowel syndrome with diarrhea predominance

ABSTRACT

Irritable bowel syndrome [IBS] is the most prevalent functional bowel disorder which is characterized by chronic abdominal pain and altered bowel habit in the absence of any organic disease. This study examined the effects of "relaxation and citalopram" in comparison to "citatopram" alone on alleviating the symptoms of IBS patients with diarrhea predominance. This study was a randomized clinical trial which included 64 IBS patients. The patients were selected according to Rome-Ill criteria, and were divided into two groups. Bowel Symptoms Severity and Frequency Scale [BSS-FS] was used for evaluation of the patients' symptoms. Data was analyzed using analysis of covariance [ANCOVA]. There were significant differences in the severity and frequency of IBS symptoms between two groups after the study period regarding BSS-FS [P<0.05]. However, no significant difference was observed at follow-up stage between two groups [P > 0.05]. Relaxation in addition to citalopram in IBS patients with diarrhea predominance can decrease the severity and frequency of symptoms. However, stopping this treatment may lead to recurrence of the symptoms