Serum reverse triiodothyronine in nephrotic patients

ABSTRACT

This work included fifteen nephrotic patients [eight females and seven males] in addition to ten healthy control subjects [six females and four males]. Patients and controls were subjected to the following investigations; serum thyroxine, triiodothyronine, thyroxine binding globulin, thyroid stimulating hormone and reverse triiodothyronine. The results showed that patients with nephrotic syndrome had low mean total serum thyroxine T4[5.99 +/- 0.41 Ugm/dl] and thyroxine binding globulin TBC levels [23.1 +/- 0.38 Ugm/dl]. The mean serum reverse triiodothyronine levels were within normal, while T3/T4 ratio was higher in nephrotic patients than the control subjects. Patients with nephrotic syndrome and ascites had a lower TBG than nephrotic patients with no ascites. Patients with nephrotic syndrome with serum creatinine levels more than 2 mg/dl had a significantly higher rT3 than nephrotic patients with normal kidney functions