Dendritic cells bearing HLA-G inhibit T-cell activation in type 1 diabetes
Iranian Journal of Allergy, Asthma and Immunology. 2007; 6 (1): 1-7
en Inglés
| IMEMR
| ID: emr-94103
ABSTRACT
HLA-G is normally expressed on human trophoblast cells. It is a non-classical MHC molecule class I b. The role of HLA-G in diabetic type 1 is not known. We investigated the role of IFN-beta in induction HLA-G expression on the monocyte derived dendritic cells [DC] in diabetes type 1. Treatment of dendritic cell with IFN-beta in vitro from diabetic patients [n=20] and normal subjects [n=20] resulted to the production and expression of HLA-G on these cells from both groups. However, comparison of DC from the diabetic patients with DC from the controls revealed lower levels of HLA-G molecules in DC from diabetic patients. Using mixed lymphocyte reaction [MLR], it was found that DC expressing HLA-G mediated the inhibition of autologous T cell activation. It is concluded that IFN-beta can increase HLA-G in DC from diabetic patients; subsequently it may prevent the immune regularly pathway in the diabetic pathogenesis
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Células Dendríticas
/
Antígenos de Histocompatibilidad Clase I
/
Autoinmunidad
/
Interferón beta
/
Antígenos HLA
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Iran. J. Allergy Asthma Immunol.
Año:
2007
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