C-reactive protein and acute coronary syndrome: Comparison of conservative and interventional management

ABSTRACT

Inflammation plays a key rote in the initiation and progression of atherosclerosis, the most common cause of acute coronary syndrome. C-reactive protein [CRP] that enhances plaque inflammation is synthesized six hours after myocardial infarction. High sensitivity C-reactive protein was measured by Immunoturbiditory method in 50 healthy controls and 100 patients of acute coronary syndrome on conservative or interventional management. Serum C-reactive protein levels [mg/L +/- SEM] at the time of admission were significantly raised in patients of acute coronary syndrome [11.90 +/- 2.30] as compared to controls [2.30 +/- 0.18] and further increased progressively during 24 hours of follow up period. C-reactive protein levels also increased significantly in patients who underwent interventional management [115.90 +/- 7.73] as compared to those who were on conservative management [22.28 +/- 5.54]. Serum C-reactive protein levels were found to be significantly raised in patients with acute coronary syndrome as compared to controls. In addition, patients undergoing interventional management had higher C-reactive protein levels, post intervention, as compared to those on conservative management