Effect of prophylactic antibiotic on the prevalence of pelvic inflammatory in women using IUD

ABSTRACT

Intra uterine device [IUD] is a highly effective contraceptive method but concerns about the risk of upper genital tract infection, often limits its use. Scientist believed that prophylactic antibiotic administration around the time of inserting IUD significantly reduces the risk of IUD related pelvic inflammatory disease [PID]. This study is designed to investigate the effect of prophylactic antibiotic on pelvic inflammatory disease associated with IUD insertion. This is a randomized clinical trial. A total of 500 prospective IUD [TCU-380A] users were randomly assigned in two groups. The first group received 200 mg of Doxycycline one hour before IUD insertion and the second did not. Then, 20 days after IUD insertion, the two groups were examined for PID. Data was analyzed using Mann-Whitney and Chi square tests. The mean of age, gravida, para, live children and abortion in case and control groups were not statistically significant. The rate of PID was 2.1% in case group compared to 1.9% in control group, which was not statistically significant. Vaginal infection in control group was more than case group but not significant. We concluded that the use of prophylactic antibiotic did not have a significant effect on preventing IUD induced PID. Regarding the side effects of unnecessary antibiotic consumption it is suggested to reinforce the need for implementing aseptic techniques during IUD insertion