Comparative study of antisecretory activity of four anticholinergic drugs and cimetidine on basal gastric secretion in pylorus ligated intact rats

ABSTRACT

Antisecretory effect of four anti-cholinergic drugs-atropine sulphate, propantheline bromide, oxyphencyclimine hydrochloride and hyoscine-N-butylbromide, and H2-histamine receptor antagonist cimetidine were compared on basal gastric secretion, volume and acidity, in pylorus ligated rats and their ED50 determined. Atropine was found to be the most potent followed in that order by propanthieline, cimetidine, oxyphencyciimine and hyoscine-N-butyl, Relative importance of acetylcholine in normal gastric secretion is also discussed