Long acting thyroid stimulator in Grave's diseases

ABSTRACT

Fifty eight patients suffering front Graves Disease [GD] and 30 normal healthy controls were studied to evaluate some of the immunological aspects of etiopathogenesis of Graves' Disease. Patients of GD included 14 first reported patients 22 hyper thyroid patients on drgus and 22 euthyroid patients in remission GD patients were diagnosed on the basis of clinical history, physical examination and laboratory investigations such as Radio Active Iodine Uptake .[RAIU] Serum Tri-iodothronine [T3] and Serum Thyroxine [T4] by Radio-immunoassay and thyroid scintigram. Mckenzie. Mouse Biological Assay was performed to detect and estimate Long Acting Thyroid Stimular [LATS] in GD -orients. Sixty four percent first reported and 54% hyperthyroid patients on drugs were LATS positive. LATS-Response Index [LATS-RI] was calculated in all LATS positive patients. This study, first of its kind in Pakistan, confines the presence of auto-antibodies in GD patients and is expected to stimulate further work in auto-immune thyroid disease in country