Treatment of gram-negative infections with aztreonam

ABSTRACT

Twenty-three patients with serious gram-negative infections were treated with aztreonam. Twenty-two of these were clinical and microbiological cures. No bacteria became resistant. The infections treated were of urinary tract, respiratory tract, skin/soft tissue, bones, joints intra-abdominal and septicaemia. The bacteria responsible for these infections included, E. coli, pseudomonas aeruginosa, scrratia marcescens, citrobacter, haemophilus, klebsella and enterobacter, Aztreonam was well tolerated and was found highly effective against gram-negative bacilli including P-aeuroginpsa. In view of the relative safety, unique properties and excellent clinical and bacteriologic efficacy of aztreonam this agent would appear to be an outstanding alternative to aminoglycoside therapy in serious, gram-negative infections. It is however, expensive