Beta-endorphin plasma levels in normoprolactinaemic polycystic ovarian syndrome
Population Sciences. 1992; 12: 65-74
en Inglés
| IMEMR
| ID: emr-95485
ABSTRACT
Twenty eight women with polycystic ovarian syndrome [PCO] and ten fertile regularly menstruating, weight-matched, non-pregnant controls with serum prolactin [PRL] levels below 20 ng/ml were studied in the mid-follicular phase for serum LH, FSH, oestradiol, testosterone and B-endorphin. Fifty mg clomiphene citrate was given initially for 5 days starting on the 3rd day of spontaneous menses or withdrawal bleeding. Blood samples were obtained initially and 3 and 6 months post-therapy. Samples were analysed for LH, FSH, oestradiol, testosterone and B-endorphin. There was insignificant change in the level of FSH between the PCO group and the control one. While in the LH level there was a significant gradual decrease after the 3rd and 6th month of clomiphene therapy. Also, LH/FSH ratio showed a significant decrease. The serum oestradiol levels showed a statistical significant increase after the 3 rd month of therapy while serum testosterone showed a significant decrease on clomiphene therapy. The increases of B-endorphin in PCO patients than in controls was highly significant and significantly decreased after 6 cycles of therapy. However, it remained higher than in controls. There was significant positive correlation between LH level and plasma B-endorphin levels in both PCO patients and control cases. But there was no significant correlation between plasma B-endorphin and serum level of FSH, oestradiol, testosterone and LH/FSH ratio
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Síndrome del Ovario Poliquístico
/
Prolactina
/
Testosterona
/
Sangre
/
Hormona Luteinizante
/
Estradiol
/
Hormona Folículo Estimulante
Idioma:
Inglés
Revista:
Popul. Sci.
Año:
1992
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