Effect of cimetidine and suxamethonium on neuromuscular transmission

ABSTRACT

Neuromuscular blocking activity of cimetidine was investigated on intact sciatic nerve-tibialis anterior muscle preparation of dogs. Then effects of cimetidine were observed on preparations in which partial neuromusular blockade was induced by suxametholonium. It was found that cimetidine in intravenous dose of 10 mg/kg body weight caused a partial neuromuscular blockade and it also increased the inhibitory response of suxamethonium on neuromuscular transmission