HELLP syndrome in severely-eclampsia and the outcome of pregnancy

to study the relationship between the severity of pre- eclampsia in one hand and liver functions, haemolysis of the red blood cells, platelet count and volume and the outcome of pregnancy in the other hand. Subjects This work comprised 75 pregnant cases classified into 3 groups [25 cases each]. group I: normal pregnancy in the third trimester, group II mild pre-eclampsia, group III severe pre-eclampsia. Venous blood samples were obtained for assessment of Liver functions [total serum protein, serum albumin and globulins, serum transaminase, serum bilirubin, and prothrombin time] and assessment of blood cellular elements [platelet count and volume and abnormal red blood cells]. Results A highly significant change in the liver function tests, decrease in platelet count, mean birth weight and apgar scores and a highly significant increase in mean platelet volume, RBCs fragmentation and incidence of stillbirths in severe pre-eclampsia as compared with normal pregnancy. Conclusion: Any pregnant woman in the third trimester, pre-eclamptic or having symptoms and / or signs of HELLP syndrome, must undergo, Laboratory investigations to verify or exclude HELLP syndrome, which has grave maternal and perinatal consequences