Effect of medroxy progesterone acetate on rabbit testis

ABSTRACT

Sixty sexually mature, male rabbits were divided into groups Al, A2, A3, A4, A5 and AG were given MPA for one to three months. The animals of groups Al, A3 and A5 were sacrificed at monthly intervals for three months to determine the effects on spermatogenesis while animals of groups A2, A4 and A6 were kept for a futher one to three months to check the recovery of spermatogenesis and then sacrificed. Testes were removed and studied for various parameters. In groups Al, A3 and A5, there was sequential regression of spermatogenesis but it was most f marked and swift in group A5. There was a sequentail recovery of sepermatogensis in groups A2, A4 and AG, but it was most marked and complete in group AG. MPA can be used as an effective and reversible male contraceptive but it possesses a few adverse side effects