Expression of HLA-class I and II, ICAM-1 and CD44 antigens in transitional csll carcinoma of bladder

ABSTRACT

The expression of monomorphic determinants of the histocompatibility leucocyte antigens [HLA] class I and class II, ICAM-1 and CD44 were studied using immunochemical staining of bladder tissue specimens from 30 cases of transitional cell carcinoma [TCC] of bladder. The results indicated that HLA-class I antigens were relatively well preserved in low grade cases but high grade tumors, either lacked or had markedly reduced HLA-class I antigens. Statistical analysis showed a significant difference between tumor grade in the expression of these molecules [p<0.05]. Aberrant expression of HLA-DR was detected in 30% of cases and moderate to strong expression of ICAM-1 and CD44 molecules were observed in 43% and 50% of cases, respectively. No significant difference in ICAM-1 and CD44 expression was found in relation to differentiation of tumor cells