Effect of vitamins A, E, C and omega-3 fatty acids on lipid peroxidation in streptozotocin induced diabetic rats
Iranian Journal of Public Health. 2007; 36 (2): 58-63
en Inglés
| IMEMR
| ID: emr-97200
ABSTRACT
To assess the effect of supplementation with vitamins A, E and C and omega-3 fatty acids on lipid peroxidation in Streptozotocin [STZ] induced diabetic rats. Sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, diabetic with vitamin A, E as well as C supplementation and diabetic with omega-3 fatty acids supplementation. After four weeks of treatment the rats were anesthetized and malondialdehyde [MDA] levels were investigated in blood samples, liver and heart homogenate. In diabetic rats MDA level in plasma, liver and heart was significantly more elevated than normal control rats [P< 0.05]. Vitamin A, E and C supplementation caused significant decrease in plasma, liver and heart MDA [P< 0.05]. A significant decrease in heart MDA [P< 0.05] was observed in diabetic rats with omega-3 fatty acids supplementation. Supplementation of vitamin A, E and C and co-3 fatty acids was found to decrease lipid peroxidation to some extent in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Ácido Ascórbico
/
Vitamina A
/
Vitamina E
/
Peroxidación de Lípido
/
Ácidos Grasos Omega-3
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Depuradores de Radicales Libres
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Ratas Wistar
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Estreptozocina
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Diabetes Mellitus Experimental
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Malondialdehído
Límite:
Animales
Idioma:
Inglés
Revista:
Iran. J. Public Health
Año:
2007
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