Protective effect of vitamin C and beta-carotene against nickel-induced hepatotoxicity in rats
Al-Azhar Medical Journal. 2008; 37 (4): 507-516
en Inglés
| IMEMR
| ID: emr-97454
ABSTRACT
The present study was designed to investigate the effect of nickel sulphate [25 mg/kg diet] and to evaluate the protective effect of vitamin C and beta-carotene [200mg/kg diet] on the liver of male albino rats. Serum alanine aminotransferase [ALT] and aspartate aminotransferase [AST], superoxide dismutase [SOD] activities, lipids peroxidation as malondialdehyde [MDA] and hemoglobin concentration [Hb] were determined. The results showed that nickel sulphate administration for eight weeks induced highly significant [P<0.01] increase of ALT, AST activities and MDA level, highly significant decrease in the activity of SOD and significant [P<0.05] decrease in Hb concentration in rats. The supplementation of vitamin C simultaneously with nickel sulphate showed insignificant reduction in ALT and AST activities, highly significant increase in SOD activity and significant decrease in MDA level, while supplementation of [Beta-carotene with nickel sulphate induced a significant reduction in ALT, AST activities and MDA level with highly significant increase in SOD activity as compared with nickel sulphate treated rats. Supplementation of vitamin C or beta-carotene induced an insignificant increase in Hb concentration in rats comparing with nickel sulphate treated group
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Ácido Ascórbico
/
Ratas
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Superóxido Dismutasa
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Resultado del Tratamiento
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Estrés Oxidativo
/
Beta Caroteno
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Sustancias Protectoras
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Hígado
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Pruebas de Función Hepática
/
Malondialdehído
Límite:
Animales
Idioma:
Inglés
Revista:
Al-Azhar Med. J.
Año:
2008
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