chlamydia pneumonia an independent risk factor in ischemic heart disease?

ABSTRACT

Immune system may interplay between Chlamydia pneumoniae infection and ischemic heart disease [IHD].Major histocompatibility genes regulate innate and adaptive immunity. This study was established to shed light on the possible association between ischemic heart disease [IHD] with Chlamydia pneumoniae infection and HLA antigens. Microlymphocytotoxicity assay has been applied for HLA-typing of 150 blood samples of 100 IHD patients and 50 healthy normal controls, In addition enzyme linked immunosorbant assay [ELISA] used to detedct C pnuminiae IgA and IgG. An increased frequency of HLA-A2, B35 alleland HLA-A2-B*35 haplotype was observed for patients group versus control group with P-value [0.0001, 0.05, and 0.001] respectively. This finding demonstrated that the HLA-B35 positive haplotypes confer the C.pneumoniae-related risk for IHD. HLA-DR3,DR4 and DR7 might play a role in AIH susceptibility