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Ultrasound-guided intraperitoneal cisplatin after the maximum cytoreductive surgery of pseudomyxoma peritonei
Bulletin of Alexandria Faculty of Medicine. 2008; 44 (4): 729-734
en Inglés | IMEMR | ID: emr-99555
ABSTRACT
In the past, pseudomyxoma peritonei was considered an incurable disease and often no active treatment was given. With the advent of cyto-reductive surgery, including peritonectomy procedures and intra peritoneal chemotherapy, long-term survival of these patients became actually possible. To study the impact of the intraperitoneal hyperthermic chemotherapy [cisplatin], when locally administered in patients who presented with pseudomyxoma peritonei and were treated by extensive cyto-reductive surgery. Nine patients with and. peritoneal adenomucinosis or carcinomatosis arising from the appendix who presented with a clinical picture of pseudomyxoma peritonei were diagnosed, and treated by cyto-reductive surgery followed by 6 cycles of ultrasound-guided intraperitoneal hyperthermic cisplatin. Following aggressive surgical approach and intraperitoneal chemotherapy, 7 patients had 1 year disease free survival, achieved independent activity in daily living and had an improved quality of life. The other 2 patients developed recurrences at 8 and 10 months following the completion of treatment. No major [grade III] texicities were observed. Pseudomyxoma peritonei is a treatable condition that may result in long-term disease free survival. Successful management can be achieved by combining cyto-reductive surgery and intraperitoneal hyperthermic chemotherapy
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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Patología / Procedimientos Quirúrgicos Operativos / Biopsia / Antígeno Carcinoembrionario / Tomografía Computarizada por Rayos X / Tasa de Supervivencia / Ultrasonografía / Cisplatino / Inyecciones Intraperitoneales / Metástasis de la Neoplasia Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Bull. Alex. Fac. Med. Año: 2008

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Índice: IMEMR (Mediterraneo Oriental) Asunto principal: Patología / Procedimientos Quirúrgicos Operativos / Biopsia / Antígeno Carcinoembrionario / Tomografía Computarizada por Rayos X / Tasa de Supervivencia / Ultrasonografía / Cisplatino / Inyecciones Intraperitoneales / Metástasis de la Neoplasia Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Bull. Alex. Fac. Med. Año: 2008