Limited proteolysis of human and rabbit immunoglobulins by snake venoms produces Fab-like fragments
Braz. j. med. biol. res
;
23(12): 1233-5, 1990. ilus
Artículo
en Inglés
| LILACS
| ID: lil-103649
ABSTRACT
Rabbit and, to a lesser extent, human immunoglobulins (IgGs) are cleaved by snake venoms. The snake venom proteases active on IgGs release fragments which behave on SDS-PAGE like Fab units similar to those release by the thiol-activated enzymes. However, in contrast to the cysteine proteases, the activity of snake venom proteases on IgGs is not only blocked by metal chelating agents but is also inhibited by thiol compounds. The snake enzymes active on IgG are metalloproteases
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Índice:
LILACS (Américas)
Asunto principal:
Venenos de Serpiente
/
Inmunoglobulina G
/
Fragmentos Fab de Inmunoglobulinas
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1990
Tipo del documento:
Artículo
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