Insulin resistance in essential hypertension
Braz. j. med. biol. res
;
23(12): 1253-7, 1990. tab
Artículo
en Inglés
| LILACS
| ID: lil-103652
ABSTRACT
To determine the possible existence of a relationship between insulin resistance and sympthetic nervous system activity in essential hypertension, we calculated the double cross index for 14 hypertensive sujects and 14 normotensive subjects submitted to the oral glucose test. Plasma glucose and insulin levels were similar in hypertensive and normotensive subjects. After glucose loading, however, both parameters were significantly higher in hypertensive subjects. Five out of 14 hypertensive patients were hyperinsulinemic. The increase in double cross index following a glucose load was significantly higher in normotensive volunteers than in hyperinsulinemic hypertensive subjects. No change in double cross index was observed in normoinsulinemic hypertensive subjects. Thus, insulin resistance, high blood glucose level, impairment of cardiac response and hyperinsulinemia are present in a significant portion of hypertensive patients. Hyperinsulinemia may contribute to hypertensión by stimulating sympathetic nervous system activity, by influencing the calcium transport across the cell membrane and/or by some other mechanism
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Índice:
LILACS (Américas)
Asunto principal:
Sistema Nervioso Simpático
/
Glucemia
/
Resistencia a la Insulina
/
Hipertensión
/
Insulina
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1990
Tipo del documento:
Artículo
/
Congreso y conferencia
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