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Intragastric infection of conventional and germfree mice with Giardia lamblia
Braz. j. med. biol. res ; 25(4): 349-52, 1992. ilus
Artículo en Inglés | LILACS | ID: lil-109038
RESUMO
The effects of experimental infection with Giardia lamblia were studied in 30-day old conventional and germfree CFW mice (7 animals in each group) of both sexes. Cysts were observed in the feces of both groups 6 to 7 days after intragastric infection of each animal with about 2.5 x 10 5 G. lamblia trophozoites. Fecal cyst level was statisticaly higher in germfree mice (abouth 10 5 cysts/g feces) when compared with the conventional group (about 10 4 cysts/g feces). The peak of infection in the conventional group apparently occurred on the 10th day after infection as indicated by an increase of fecal weight and by histopathological examination. Intense infiltration of the lamina propria and high reactional hyperplasia of the lymphoiud component were observed in the conventional group. There was no infiltration or hyperplasia in germfree infected mice and fecal weight was relatively constant throughout the experiment. These results suggest that, as is the case for other intestinal pathogenic protozoa, the intestinal microflora is indispensable for the expression of the pathogenicity but not for the multiplication of G. lamblia
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Índice: LILACS (Américas) Asunto principal: Enfermedades Gastrointestinales / Giardia / Infecciones / Intestinos Límite: Animales Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 1992 Tipo del documento: Artículo

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Índice: LILACS (Américas) Asunto principal: Enfermedades Gastrointestinales / Giardia / Infecciones / Intestinos Límite: Animales Idioma: Inglés Revista: Braz. j. med. biol. res Asunto de la revista: Biologia / Medicina Año: 1992 Tipo del documento: Artículo