Differential modulatory effect of IL-5 on MHC class II expression by macrophages and B cells
Braz. j. med. biol. res
;
25(5): 509-13, 1992. ilus
Artículo
en Inglés
| LILACS
| ID: lil-109058
RESUMO
The present study examines the effect of interleukin 5 on the expression of class II major histocompatibility complex (MHC) in macrophages and B cells. treatment of splenic adherent cells, a population that contains mostly macrophages and dendritic cells, with 100 U/ml of recombinant interleukin 5 resulted in a decrease of 10 to 30% in cell surface MHC class II expression by macrophages. The treatment had no effect on class I MHC expression, or on the mRNA synthesis as evaluated by tritiated-uridine incorporation. The same treatment of B cells resulted in the delineation of two groups with regard to class II MHC expression in a previously more homogeneous population. One group had an increase in surface Ia expression and the other had a decrease in the expression of this molecule. These results suggest that interleukin 5 has a role in MHC class II regulation
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Índice:
LILACS (Américas)
Asunto principal:
Linfocitos B
/
Interleucina-5
/
Macrófagos
/
Complejo Mayor de Histocompatibilidad
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1992
Tipo del documento:
Artículo
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