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Mini-review: the ultrasonographical and serological chanbges and their improvement after praziquantel treatment Schistosoma japonicum infected patients in Leyete, Philippines
Mem. Inst. Oswaldo Cruz ; 87(supl.4): 277-80, 1992.
Artículo en Inglés | LILACS | ID: lil-125663
ABSTRACT
We have identified the specific ultrasonographical (US) changes in Schistosoma japonicum infected patients with the serological changes in general liver function markers. The US examination with the following haematological and biochemical serum analysis was performed on 102 patients in Shistosomiasis Hospital, Leyte, Philippines. The US liver images were classified into 4 patterns according to the development of periportal fibrosis and the patterns of echogenic bands. Among various haematological and biochemical serum parameters of liver damage. The serum levels of total bile acid (TBA) and procollagen-III-peptide (P-III-P) correlated well with the development of hepatic fibrosis and the portal hypertension. These patients were subsequently treated with praziquantel (3 x 20 mg/kg), and improvement of the thickening of the portal vein wall and the dintensity of the echogenic band formation was detected 6 months after treatment. The significant US changes could not be detected in the patients with severe hepatic fibrosis caused in the long term infection. The results revealed that the US examination with the serum TBa level would provider a sensitive tool monitor the severity of the infection and also the improvement occured shortly after praziquantel treatment
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Praziquantel / Procolágeno N-Endopeptidasa / Ultrasonido / Esquistosomiasis Japónica / Pruebas Serológicas Tipo de estudio: Estudio diagnóstico Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 1992 Tipo del documento: Artículo

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Praziquantel / Procolágeno N-Endopeptidasa / Ultrasonido / Esquistosomiasis Japónica / Pruebas Serológicas Tipo de estudio: Estudio diagnóstico Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 1992 Tipo del documento: Artículo