The mechanism of low testosterone levels in homozygous sickle-cell disease
West Indian med. j
;
43(1): 12-4, Mar. 1994.
Artículo
en Inglés
| LILACS
| ID: lil-130569
ABSTRACT
Significantly lower testosterone levels are common in male patients with homozygous sickle-cell (SS) disease and have been attributed to either abnormalities of the hypothalamo-pituitary axis or primary testicular failure. The mechanism has now been investigated by observing the response to gonadrotropinthytotropin releasing hormones (GnRH-TRH) in 10 male patients with SS disease and in 10 matched male sibling controls without sickle-cell disease. Mean basal levels of luteninizing hormone (LH) follicular stimulating hormone (FSH) and thyrotropin (TSH) were significantly elevated but prolactin (RL) levels were within the normal range in the SS group. All hormones increased following GnRH-TRH, and proportionate increases over baseline were similar for FSH and TSH in SS and AA subjects, but SS patients showed a lesser percentage increase in LH at 30 minutes, and a higher percentage increase in PRL at 60 minutes. These observations are more consistent with primary testicular failure than with adnormalities of the hypothalmic-pituitaty-testiculat axis.
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Índice:
LILACS (Américas)
Asunto principal:
Enfermedades Testiculares
/
Testosterona
/
Hormona Liberadora de Gonadotropina
/
Anemia de Células Falciformes
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
West Indian med. j
Asunto de la revista:
Medicina
Año:
1994
Tipo del documento:
Artículo
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