Respuesta fibrinolítica a la 1-deamino-8-angina vasopresina (DDAVP) en pacientes con alteraciones de la hemostasia / Fibrinolytic response of 1-deamino-8-D-arginine vasopresin (DDAVP) in patients with hemostasis alteration
Bol. Acad. Nac. Med. B.Aires
; 71(1): 81-4, jun. 1993.
Article
en Es
| LILACS
| ID: lil-136692
Biblioteca responsable:
AR1.1
ABSTRACT
Decrease fibrinolytic response after infusion of 1-deamino-8-D-arginine vasopressin (DDAVP) was reported in patients with von Willebrand disease (vW) (Nouv. Rev. Fr.Hematol.1992, 3455-60), suggesting an association between vW factor and syntesis or/and realese of t-PA by endothelial cells. In the present study we measured the activity of plasmatic euglobulin fractions by fibrin plate method in 65 patients with hemostatic disorders 36 vW type I, 9 hemophilics A (HA), 6 storage pool disease (SPD), 6 primary hemostasis alteration (PHA), 8 PHA and decrease factor VIII (PHAH), and 5 normals (N). DDAVP was administrated intravenously at 0,4 ug/Kg body weight. The means SD (mm) of the difference between the diameter of lysis area from the highest and basal response were N 4,60ñ1,55; vWd 6,38ñ2,77; HA 4,77ñ2,95; SPD 4,9ñ1,69; PHA 5,63ñ4,3PHAH 4,35ñ2.09. No statistical difference was obtained between N and patients. A higher than normal fibrinolytic response was observed in vW 12/365, HA 2/9, PHA 2/6, PHAH 2/8. A decrease response was showed by vWd 0/36, HA 1/9, SPD 0/6, and PHAH 0/8. Our observation suggest that the FvW is not related with the plasmatic fibrinolytic activity
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Índice:
LILACS
Asunto principal:
Enfermedades de von Willebrand
/
Desamino Arginina Vasopresina
/
Fibrinólisis
/
Hemostasis
Límite:
Humans
Idioma:
Es
Revista:
Bol. Acad. Nac. Med. B.Aires
Asunto de la revista:
MEDICINA
Año:
1993
Tipo del documento:
Article