Lipoproteína (a) y otros factores de riesgo en niños chilenos con diabetes mellitus tipo I / Lipoprotein (a) and other risk factors in chilean children with diabetes mellitus type I
Rev. méd. Chile
;
122(10): 1115-9, oct. 1994. tab, ilus
Artículo
en Español
| LILACS
| ID: lil-143985
RESUMO
Aims- To study serum Lp(a) levels and other metabolic cardiovascular risk factors in children with type I diabetes mellitus (DM) in comparison with sex and age matched nondiabetic children. To determine the influence of diabetes control on serum lipoprotein (a) concentrations. Design- Transversal observational study. Target population diabetic group 70 type I DM children with microalbuminuria and no macro-microvascular nor neurological complications, aged from 8 to 15 years; 30 boys, 40 girls. Mean duration of type I DM was 8 ñ 4 years. Non diabetic group composed by 123 healthy children with no family history of DM, aged from 8 to 15 years, 53 boys, 70 girls. Methods- The lipids profile include total cholesterol (TC) and triglyceride (TG), cholesterol high-density lipoproteins (C-HDL) cholesterol very-low-density lipoproteins (C-LDL) and cholesterol low-density lipoproteins (C-LDL). ApoAI, APOAII and ApoB, Lp(a) and fructosamine. Results- Fructosamine concentration in diabetic children was 340 ñ 108 uM/1 in 240 ñ 25 uM/I nondiabetic children. Lp(a) serum levels did not significantly differ among both groups 17 ñ 16 mg/dl in diabetics 19 ñ 18 mg/dl in controls. Multivariate analysis showed that in the diabetic children the worsening of metabolic control as reflected by fructosamine, was positively correlated with the increase in total Lp(a) serum concentration. Conclusions- In children aged 8-15 years with uncomplicated IDDM lasting less than 15 years duration (Lp(a) serum levels are positively correlated with the poorest metabolic control
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Índice:
LILACS (Américas)
Asunto principal:
Lipoproteína(a)
/
Diabetes Mellitus Tipo 1
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Adolescente
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Chile
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
1994
Tipo del documento:
Artículo
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