Proteínas de la leche y su asociación con diabetes mellitus insulino-dependiente / Milk proteins and it association with insulin dependent diabetes mellitus

RESUMO

Cow`s milk has been implicated as a possible trigger of the autoinmune respose that destroys pancreatic beta cells in genetically susceptible host, thus causing diabetes mellitus. Studies in animals have suggested that bovine serum albumin, BSA, is the milk protein responsible, and an albumin peptide containing 17 amino acids, ABBOS, may be the reactive epitope. Antibodies to this peptide react with p69 a beta cell surface protein that may represent the target antigen for milk-induced beta-cell specific inmunity. The consumption of cow`s milk in Europe may support the hypothesis that cow`s milk may be a triggering factor for the development of type I diabetes. However, several epidemiological studies has not found significance correlation between the observed the importance of several enviromental factors in the devepment of type I diabetes with the objetive to establish a good prevention in susceptible subjects: