HLA y diabetes mellitus insulino-dependiente / HLA and insulin-dependent diabetes mellitus
Rev. méd. Chile
; 122(12): 1413-20, dic. 1994. tab, ilus
Article
en Es
| LILACS
| ID: lil-144181
Biblioteca responsable:
CL1.1
ABSTRACT
The propensity of an individual to develop type I (insulin dependent) diabetes mellitus is directly related to specipic HLA clase II proteins, specially those from DR and DQ regions. Genetic susceptibility to insulin dependent diabetes arises from a preestablished conformation of alpha and ß chains of DQ and ß chain of DR. Since the classic demonstration by McDevitt and colleagues that DQ ß chain aspartate at position 57 was protective against the development of the disease, many populations have been surveyed to study the association between the incidence Type I diabetes and determined frequencies of DR and DQ haplotypes. The assocation between these markers and susceptibility to Type I diabetes is well established in caucasians at the present time. However, little information is available for Latin American populations, that share a mixture of european, african and native genes. Our group is studying genetic markers of three Latin American populations (Argentina, Perú and Chile) and their possible association to the different incidence of Type I diabetes mellitus in each country
Buscar en Google
Índice:
LILACS
Asunto principal:
Antígenos HLA-DP
/
Antígenos HLA-DQ
/
Antígenos HLA-DR
/
Diabetes Mellitus Tipo 1
/
Complejo Mayor de Histocompatibilidad
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
Es
Revista:
Rev. méd. Chile
Asunto de la revista:
MEDICINA
Año:
1994
Tipo del documento:
Article