Effects of a single administration of buspirone on catalepsy, yawning and stereotypy in rats
Braz. j. med. biol. res
;
26(1): 71-4, Jan. 1993. tab
Artículo
en Inglés
| LILACS
| ID: lil-148675
ABSTRACT
In the present study, the effects of a single administration of buspirone (0.1, 0.3, 1.0, and 3.0 mg/kg sc-30 min before testing) on three dopamine-related behaviors were evaluated in 4-month old male Wistar rats (7-10 animals per group). Buspirone decreased haloperidol (2.0 mg/kg ip)-induced catalepsy in a dose-dependent manner (from 7.30 to 5.09 1n of s compared to the untreated control group). Apomorphine (0.06 mg/kg sc)-induced yawning was also dose-dependently reduced (from 26.7 to 0.9 yawns in 30 min) and so was apomorphine (1.0 mg/kg sc)-induced stereotypy (from 32.9 to 5.9, sum of scores). The present results indicate that buspirone presents unique pharmacological effects related to dopaminergic transmission not only in biochemical but also in behavioral terms
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Índice:
LILACS (Américas)
Asunto principal:
Conducta Estereotipada
/
Buspirona
/
Catalepsia
/
Bostezo
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1993
Tipo del documento:
Artículo
/
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