Lipid effects on nicotinic acetylcholine receptor gating and kinetics: a structural-functional correlation
Braz. j. med. biol. res
;
26(6): 553-71, Jun. 1993. tab
Artículo
en Inglés
| LILACS
| ID: lil-148709
ABSTRACT
The nicotinic acetylcholine receptor (AChR) is still the paradigm of rapid ligand-gated ion channels. Since the early finding of a motionally restricted shell of lipids ( annulus ) in the immediate perimeter of the membrane-bound AChR, experimental evidence has supported the notion that the interface between the protein moiety and the adjacent lipid molecules is the site of action of a variety of pharmacologically relevant substances, including non-competitive inhibitors of the cholinergic system like some local anesthetics, short-chain alcohols, and steroids. Patch-clamp data on cells expressing the AChR protein add another dimension to this knowledge, enabling correlations to be established between the chemical composition of lipid-modified cells and the functional properties (ligand binding, channel gating) of the receptor protein in situ
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Índice:
LILACS (Américas)
Asunto principal:
Activación del Canal Iónico
/
Receptores Nicotínicos
/
Lípidos de la Membrana
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1993
Tipo del documento:
Artículo
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