Effect of conbined administration of counterregulatory hormones during insulin-induced hypoglycemia in rats: lipolysis mediated by a Beta-adrenergic mechanism contributes to hyperglycemia
Braz. j. med. biol. res
;
27(12): 2883-7, Dec. 1994. graf
Artículo
en Inglés
| LILACS
| ID: lil-153288
ABSTRACT
The synergistic effect of combined injection of glucagon (G), cortisol (C) and phenylephrine + isoproterenol (E) during hypoglycemia in male adult Wistar rats was investigated. For this purpose we injected insulin (1 mg/kg), individually or combined (G+C, G+E, C+E and C+G+E). All drugs were injected ip and all rats were killed 60 min after insulin injection. The rise in glycemia with C+G+E was greater (delta = 107 mg/dl) than the sum of the responses to injection of C, G and E individually, or in double combination plus any single hormone injection. This synergistic effect was reproduced by G + C + isoproterenol (Iso) but not by G + C + phenylephrine (delta = 0 mg/dl). The results also showed a clear relationship between hyperglycemia and lipolysis. Thus, lipolysis mediated by a ß-adrenergic mechanism played a significant role in promoting hyperglycemia when Iso was combined with G and C
Buscar en Google
Índice:
LILACS (Américas)
Asunto principal:
Glucagón
/
Hidrocortisona
/
Hipoglucemia
/
Insulina
Límite:
Animales
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
1994
Tipo del documento:
Artículo
/
Congreso y conferencia
Similares
MEDLINE
...
LILACS
LIS