El sistema mayor de histocompatibilidad como factor de riesgo de la enfermedad hepática alcohólica / Major histocompatibility system as a risk factor of alcoholic hepatic disease
Rev. méd. Chile
;
123(6): 687-93, jun. 1995. tab
Artículo
en Español
| LILACS
| ID: lil-156937
ABSTRACT
Several associations between alleles of the major histocompatibility system and alcoholic liver disease have been described. However, these are weak and changes from one population to another. The aim of this work was to search for a possible genetic risk factor for alcoholic liver disease among chilean alcoholics. We studied blood groups, serum proteins and HLA antigens in 39 alcoholic cirrhotics, 104 asymptomatic alcoholics and 44 non alcoholic controls. Asymptomatic alcoholics were also subjected to a percutaneous liver biopsy that showed moderate to severe histological liver damage in 46 subjects (44 percent). No differences in the studied genetic markers, were found among the four groups. It is concluded that this study does not confirm previously reported associations between genetic markers and alcoholic liver disease
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Índice:
LILACS (Américas)
Asunto principal:
Cirrosis Hepática Alcohólica
/
Complejo Mayor de Histocompatibilidad
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
1995
Tipo del documento:
Artículo
/
Documento de proyecto
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