Assessment of immunity induced in mice by glycoproteins derived from different strains and species of Leishamnia
Mem. Inst. Oswaldo Cruz
; 91(1): 63-70, Jan.-Feb. 1996. tab, graf
Article
en En
| LILACS
| ID: lil-164136
Biblioteca responsable:
BR15.1
ABSTRACT
A comparative study was undertaken on the immunogenic properties of 63kDa glycoproteins obtained from five different strains/species of Leishmania and assessed in C57BL/10 mice. The humoral immune response was assessed by ELISA against the five different antigens of the immunized animals. The cellular immune response was derived from Leishmania. The response was found to be species-specific in all of determined by means of the cytokine profiles secreted by the spleen cells of immunized animals. The presence of y-IFN and IL-2, and the absence of IL-4 in the supernatants of cells stimulated by L. amazonensis antigen established that the cellular response is of Th1 type. The five glycoproteins tested were equally effective in protecting C57BL/10 mice against challenge by L. amazonensis. About 50 por cento of the immunized animals were protected for six months.
Texto completo:
1
Índice:
LILACS
Asunto principal:
Glicoproteínas
/
Leishmania
/
Ratones
Límite:
Animals
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
1996
Tipo del documento:
Article